Clinical Study of Carbon Ion Radiotherapy for Solid Tumors in Elderly Patients Aged Over 80 Years

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600124401

Enrollment

Unknown

Registered

2026-05-12

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant tumor

Interventions

Treatment group:Carbon Ion Radiotherapy

Eligibility

Sex/Gender

All

Age

80 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=80 years, regardless of gender; 2.Pathologically or cytologically confirmed solid tumors, including but not limited to non-small cell lung cancer, hepatocellular carcinoma, prostate cancer, pancreatic cancer, esophageal cancer, head and neck tumors, bone and soft tissue sarcoma; 3.Evaluated by MDT as suitable for radical radiotherapy (primary treatment or local recurrence without distant metastasis); 4.ECOG performance status 0-2; 5.Expected survival >=6 months; 6.Main organ function meets requirements;The blood routine was basically normal (HB >= 90g/L, WBC >= 3.0 × 10^9/L, PLT >= 80 × 10^9/L); Liver function child Pugh grade A or B (liver tumor); Renal function Cr <= 1.5 × ULN; Cardiopulmonary function can tolerate lying on the back for 30 minutes; 7.Voluntarily sign informed consent and cooperate with follow-up; 8.Not participating in other similar clinical studies.

Exclusion criteria

Exclusion criteria: 1. Severe cardiopulmonary failure, unable to lie flat for 30 minutes; 2. Cognitive dysfunction, unable to cooperate with treatment positioning and irradiation; 3. Severe uncontrolled comorbidities: such as uncontrolled hypertension, diabetic ketoacidosis, active infections, etc.; 4. Terminal patients with an expected survival of <3 months; 5. Previous radical radiotherapy at the same site (re-irradiation requires strict MDT evaluation and must meet the indications for re-irradiation); 6. Extensive distant metastases not suitable for local radical treatment; 7. Pregnancy or breastfeeding (rare in elderly women, but still needs to be ruled out); 8. Other conditions deemed unsuitable for enrollment by the physician (such as severe malnutrition, severe frailty, etc.).

Design outcomes

Primary

Measure	Time frame
Incidence and severity of acute and chronic toxicities;	—

Secondary

Measure	Time frame
Local control rate;Objective response rate;Progression-free survival;Overall survival;	—

Countries

China

Contacts

Public ContactZhang Yanshan

Gansu Wuwei Tumor Hospital

13830510999@163.com+86 138 3051 0999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026