Peroperative general anaesthesia (propofol-associated molecular responses)
Conditions
Interventions
Cohort of surgical patients undergoing propofol general anesthesia:None
Sponsors
Luxian County People 's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years; 2. ASA physical status class I–II; 3. Scheduled for elective surgery under general anesthesia, with propofol planned as the primary anesthetic agent in the clinical anesthesia protocol; 4. Well-compensated cardiopulmonary function; 5. Willing to participate in this study and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with concurrent central nervous system disorders, psychiatric disorders, or persistent neurological deficits; 2. Patients with concurrent active infections, autoimmune diseases, or immunodeficiency, or those who have used glucocorticoids or immunosuppressants within the past month; 3. Patients with severe cardiac, pulmonary, hepatic, or renal dysfunction; 4. Pregnant or breastfeeding women; 5. Patients deemed ineligible for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the Composition of Major Immune Cell Subpopulations in PBMCs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cellular communication and regulatory networks;Changes in iron-deficiency-related gene sets and pathway scores;Changes in neurotoxicity-related pathways;Comparison of changes in the expression of ferroptosis-related gene sets and pathway activity between T0 and T1; | — |
Countries
China
Contacts
Public ContactHe Tianping
Luxian County People 's Hospital
Outcome results
None listed