SLE patients with cognitive impairment versus those without cognitive impairment
Conditions
Interventions
Healthy control group:None
Group SLE:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Patients meeting the 2019 EULAR/ACR classification criteria for SLE; 2. Voluntary participation with signed informed consent; 3. Age between 18 and 50 years; 4. Right-handedness. Control group:; 1. Age and gender matched with patients; 2. In good health; 3. Voluntary participation with signed informed consent; 4. Age between 18 and 50 years; 5. Right-handedness.
Exclusion criteria
Exclusion criteria: 1. Comorbid other autoimmune diseases; 2. History of hypertension, diabetes, stroke, renal insufficiency, or other conditions that may cause severe clinical situations such as brain atrophy; 3. History of severe traumatic brain injury or surgery; 4. Severe active psychiatric symptoms, such as severe behavioral disturbance and impaired consciousness; 5. History of substance abuse, alcoholism, or drug abuse; 6. MRI contraindications including claustrophobia or metallic implants; 7. Pregnant or lactating women. Control Group: 1. A history, either past or present, of definite physical diseases or neuropsychiatric disorders (psychiatric symptoms will be assessed/screened by an experienced psychiatrist using the Structured Clinical Interview for DSM-IV, Non-Patient Edition); 2. History of immune system diseases and family history of such diseases; 3. History of substance abuse, alcoholism, or drug abuse; 4. History of severe traumatic brain injury or surgery; 5. Pregnant or lactating women; 6. MRI contraindications including claustrophobia or metallic implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structural MRI (sMRI);MRI Conventional Scan;Cognitive Function Assessment;Diffusion Tensor Imaging (DTI);Vascular Function Marker Detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic Data;Cytokine;Lymphocyte Subset ;Autoantibody;Medical History and Treatment Data;Disease Activity Assessment/Damage Assessment; | — |
Countries
China
Contacts
Public ContactZhang Guofang
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed