Postoperative depression
Conditions
Interventions
Group A:0.25 mg/kg of esketamine was administered intravenously during anesthesia induction, and esketamine was continuously infused at a dose of 0.125 mg/(kg·h) throughout maintenance until 20 minute
Group B:During anesthesia induction, an equal volume of 0.9% saline was administered intravenously, and an equivalent amount of saline was infused throughout the maintenance phase until 20 minutes bef
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 60-80 years undergoing abdominal surgery under elective general anesthesia. 2. No restrictions on gender. 3. American Society of Anesthesiologists (ASA) physical status classification II-III. 4. Surgery duration of >=2 hours.
Exclusion criteria
Exclusion criteria: 1. A history of brain disease, brain trauma, neurological or psychiatric disorders, or mental illness; 2. Allergy to anesthetic drugs such as esketamine; 3. Long-term use of drugs that affect neuropsychiatric function; 4. Inability to complete cognitive function tests and assessments before surgery; 5. Expected difficulty in postoperative follow-up or poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-item Hamilton Rating Scale for Depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE;numerical rating scale score;Pittsburgh Sleep Quality Index, PSQI;COGi;Surgical time;Bleeding Volume;Wake-up time;Serum S100ß protein;NFL;IL-6;Pi;PTi;Sevoflurane Dosage;Propofol dosage;Dose of rocuronium;Sufentanil Dosage;Remifentanil Dosage; | — |
Countries
China
Contacts
Public ContactChen Ying
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed