Postoperative Sleep Disorders
Conditions
Interventions
Esketamine Group:Following placement of the oropharyngeal airway, continuous infusion of esketamine (infusion rate: 0.3 mg/kg/h) is initiated and maintained until the conclusion of surgery.
Control group:After placement of the laryngeal mask, initiate continuous infusion of an equal volume of normal saline (infusion rate: 0.3 mg/kg/h) until the conclusion of surgery.
Parts I :None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
Male
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Parts I (1) Elective transurethral prostate surgery under general anesthesia; (2) Age 65 to 90 years; (3) ASA physical status classification I to III; (4) Patients capable of participating in questionnaire surveys. 2.Part II (1) Elective transurethral prostate surgery under general anesthesia; (2) Age 65 to 90 years; (3) ASA physical status classification I to III; (4) Patients capable of participating in questionnaire surveys.
Exclusion criteria
Exclusion criteria: 1.Parts I (1) Patient refuses to participate in the study. (2) Preoperative Richards-Campbell Sleep Questionnaire (RCSQ) score = 50 or Athens Insomnia Scale (AIS) score > 6. (3) Use of hypnotics within the past month. (4) Recent history of substance abuse. (5) Cognitive impairment or inability to communicate. (6) Severe organ dysfunction. (7) Postoperative transfer to the ICU. 2.Part II (1) Contraindications or allergies to esketamine or other drugs used in this study. (2) Preoperative Richards-Campbell Sleep Questionnaire (RCSQ) score = 50 or Athens Insomnia Scale (AIS) score = 6. (3) Use of hypnotics/sedatives within the past month. (4) Recent history of substance abuse. (5) Cognitive impairment or communication difficulties. (6) Severe cardiopulmonary disease, severe renal impairment (requiring dialysis), or severe hepatic impairment (Child-Pugh class C). (7) Patient refuses to participate in this study. (8) Postoperative transfer to the intensive care unit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parts I :Incidence of Postoperative Sleep Disturbance;Parts I :Risk Factors for Sleep Disturbance;Part II:Incidence of Postoperative Sleep Disturbance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comorbidities (Hypertension, Diabetes Mellitus, Coronary Heart Disease, Cerebrovascular Disease); Laboratory indicators;Richards-Campbell Sleep Questionnaire (RCSQ) score;Athens Insomnia Scale (AIS) score;Hospital Anxiety and Depression Scale (HADS) score;Pain score;Quality of Recovery-15 (QoR-15) score;Richards-Campbell Sleep Questionnaire (RCSQ) score;Athens Insomnia Scale (AIS) score;Hospital Anxiety and Depression Scale (HADS) score;Pain score;Diastolic blood pressure;Delirium Assessment;Systolic Blood Pressure;Diastolic blood pressure;Average Pressure;Heart rate;Bispectral Index (BIS) value;Intraoperative anesthetic drug dosage;Surgery time;Duration of anesthesia;Time of extubation of laryngeal mask or endotracheal tube;Infusion volume;Intraoperative blood loss;Postoperative complication incidence rate;Serum melatonin;Brain-derived neurotrophic factor;Cortisol;Tumor Necrosis Factor-alpha;C-reactive protein;Interleukin-1ß;Interleukin-6;Interleukin-8; | — |
Countries
China
Contacts
Public ContactYubo Xie
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed