Gynecologic tumor
Conditions
Interventions
Control group:The control group used a patient-controlled intravenous analgesia protocol of sufentanil at 2 µg/kg diluted in 200 ml of normal saline.
Esketamine - dexmedetomidine group: In the mini-dose esketamine- dexmedetomidine group, the protocol for patient-controlled intravenous analgesia was esketamine 50 mg, dexmedetomidine 200 mg, sufentan
Sponsors
Nantong First People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age from 18 to 60 years. 2. ASA ? ~ ?. 3. Gynecological endoscopic surgery performed at an appropriate time. 4. Require patient controlled intravenous analgesia after surgery.
Exclusion criteria
Exclusion criteria: 1. Preoperative Severe sinus bradycardia (heart rate = III. 2. OSAS. 3. BMI > 30. 4. History of hyperthyroidism or pheochromocytoma, schizophrenia, epilepsy, or myasthenia gravis. 5. Severe liver and kidney dysfunction. 6. Preoperative PSQI > 7. 7. A recent history of substance abuse. 8. Contraindicated or allergic to esketamine or dexmedetomidine. 9. Cognitive dysfunction or inability to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep Quality Numerical Rating Scale (NRS);Athena Insomnia Scale (AIS);Hospital Anxiety and Depression Scale (HADS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS);The cumulative consumption of sufentanil in the analgesic pump within 48 hours postoperatively; | — |
Countries
China
Contacts
Public ContactCai Mengmeng
Nantong First People's Hospital
Outcome results
None listed