Postoperative delirium, postoperative sleep disorder
Conditions
Interventions
Magnesium sulfate Group (Group M):Perioperative infusion of magnesium sulfate
Control group (Group C):Perioperative saline infusion
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~85 years old; 2. ASA I-III level; 3. Clinical Diagnosis: Confirmed as esophageal cancer by pathology, planned to undergo radical esophagectomy via thoracoscopic and laparoscopic combined three-incision approach at an elective time; 4. Cognitive Function: Preoperative MMSE score >= 24 points (excluding baseline cognitive impairment), no clear history of cognitive impairment; 5. Liver and Renal Function: Liver function: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) = 60 mL/min/1.73m²; 6. Communication Ability: Conscious, with good communication and comprehension abilities, able to cooperate with research evaluation; 7. Informed Consent: The patient has fully understood the research content, voluntarily participated, and signed a written informed consent form;
Exclusion criteria
Exclusion criteria: 1. Severe dysfunction of vital organs: Severe cardiac insufficiency (New York Heart Association heart function class III-IV), or history of unstable angina pectoris or myocardial infarction within 6 months; severe liver insufficiency (Child-Pugh class B or C); renal insufficiency (eGFR 1.05 mmol/L) or treatable hypomagnesemia preoperatively; known allergy to magnesium sulfate or any of its components; presence of severe cardiac conduction block (e.g., second-degree or higher atrioventricular block), or sick sinus syndrome without pacemaker implantation; 3. History of mental and neurological diseases or sedative drug dependence: History of definite stroke, craniocerebral surgery, epilepsy, Parkinson's disease, myasthenia gravis, or any diagnosed neurological disease associated with dementia; history of severe mental diseases such as schizophrenia or bipolar disorder, or long-term use of antipsychotic drugs, benzodiazepines (excluding short-term preoperative sedative use);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium(POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| The quality of sleep;Postoperative Pain Score;Venous serum IL-6 concentration, TNF-a concentration;Intraoperative vital signs (electrocardiogram, blood pressure);Serum magnesium concentration; | — |
Countries
China
Contacts
Public ContactWang Jiayu
Huai'an First People's Hospital
Outcome results
None listed