Prostate cancer
Conditions
Interventions
experimental group:After anesthesia induction, start infusion 5 minutes before skin incision: Experimental group: continuously infuse magnesium sulfate at 25 mg/kg/h, maintaining intravenous infusion
if the surgery lasts longer than 4 hours, stop the magnesium sulfate infusion after continuous infusion for 4 hours.
control group:An equal volume of saline solution, administered over the same duration and at the same rate as the experimental group.
Sponsors
Shanghai Geriatric Medical Center
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18; 2.Elective laparoscopic radical prostatectomy; 3.ASA Grades I–III; 4.BMI:18-30kg/m2; 5.Providing postoperative patient-controlled intravenous analgesia (PCIA);
Exclusion criteria
Exclusion criteria: 1.Allergy to any of the medications used in this study; 2.Patients with severe hepatic impairment (Child-Pugh Class C); 3.Patients with severe renal impairment (eGFR < 15 mL/min/1.73 m²) or those with end-stage renal disease receiving renal replacement therapy; 4.Patients with neuromuscular junction disorders; 5.Patients receiving calcium channel blockers; 6.Patients with psychiatric disorders or cognitive impairment; 7.Patients with hypermagnesemia; 8.Patients with hypocalcemia; 9.Patients who refuse to sign the informed consent form for other reasons;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score 24 hours post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of sufentanil in patients receiving patient-controlled intravenous analgesia (PCIA) 24 and 48 hours postoperatively;Numerical Rating Scale (NRS) scores for patients at rest and during activity; | — |
Countries
China
Contacts
Public ContactWu Zijun
Shanghai Geriatric Medical Center
Outcome results
None listed