Post-stroke depression (PSD)
Conditions
Interventions
sham stimulation control group:In-bore simulation treatment
conventional neurological rehabilitation treatment.
Hyperbaric oxygen therapy group
sham stimulation control group.:Hyperbaric oxygen therapy
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–75 years; 2. First-ever acute ischemic or hemorrhagic stroke confirmed by CT or MRI; 3. Meeting the diagnostic criteria for "depressive disorder due to another medical condition" according to the Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5); 4. Hamilton Depression Rating Scale (HAMD-17) score >= 17, indicating at least moderate depression; 5. The patient or their legal representative has understood and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe aphasia, sensory aphasia, severe cognitive impairment (MMSE score = 3 on item 3 (suicidal ideation) of the HAMD scale, or a clear and urgent risk of self-harm or suicide as clinically assessed by the investigator; 5. Absolute contraindications to hyperbaric oxygen therapy such as untreated pneumothorax, severe emphysema, or active tuberculosis; 6. Severe cardiac, hepatic, or renal insufficiency (laboratory values > 1.5 times the upper limit of normal), or an expected survival of less than one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in quality of life;Improvement in daily living abilities;Improvement of cognitive function; | — |
Countries
China
Contacts
Public ContactYang Mei
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed