Diminished Ovarian Reserve, DOR
Conditions
Interventions
Live birth group:None
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with DOR who meet the Bologna Criteria or the POSEIDON standards (Group 3 & 4): 1.Age: 20 <= age <= 50 years; 2.Diminished ovarian reserve: AFC < 5-7 follicles and/or AMH < 1.1 ng/mL; 3.History of poor ovarian response: Number of oocytes retrieved with a conventional stimulation protocol = 3; 4.Completion of at least one full IVF/ICSI oocyte retrieval cycle, with clear documentation of pregnancy outcome follow-up;
Exclusion criteria
Exclusion criteria: 1.Concurrent severe organic uterine pathologies significantly affecting implantation (e.g., severe intrauterine adhesions, untreated submucosal fibroids, congenital uterine malformations, etc.); 2.Either partner having a confirmed chromosomal karyotype abnormality; 3.Cases where missing rates of core clinical data (e.g., key hormone levels, ovulation induction parameters, pregnancy outcomes) exceeded 20% and could not be repaired through imputation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate;Discriminative ability of the predictive model; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;Sensitivity;Net Benefit;Feature Importance Ranking and Variable Interactions: Interaction Effects and Nonlinear Associations.;calibration; | — |
Countries
China
Contacts
Public ContactShi Libing
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed