Carotid Artery Stenosis
Conditions
Interventions
Remimazolam combined with sevoflurane group (RS group):Intravenous infusion of remimazolam combined with continuous inhalation of sevoflurane
Propofol group (Group P):Continuous infusion of propofol
Sponsors
Hengshui People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. CEA is scheduled for patients with moderate to severe carotid artery stenosis confirmed by preoperative ultrasound or digital subtraction angiography; 2. No restrictions on gender, age over 18 years, BMI less than 30 kg/m^2; 3. ASA classification II or III; 4. No severe cardiovascular, cerebrovascular diseases, or abnormal liver and kidney function.
Exclusion criteria
Exclusion criteria: 1. Allergic to the drugs used in this study; 2. Abnormal preoperative muscle strength examination, with damage to the limb conduction pathway or contraindications to electrophysiological monitoring; 3. Presence of severe intracranial lesions such as bleeding or brain tumors; 4. Preoperative National Institutes of Health Stroke Scale (NIHSS) score >= 4; 5. Presence of mental and neurological diseases, cognitive dysfunction, or long-term use of sedative and analgesic drugs; 6. Presence of tandem vascular stenosis or other diseases that may interfere with study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MEP amplitude ;SEP amplitude ;MEP latency;SEP latency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological function;Time when MOAA/S score is =5;Time of tube removal;First wake-up eye-opening time;Surgical time;Carotid Artery Occlusion Time;Brain Oxygen Saturation;Anesthesia Depth ;Mean Arterial Pressure; | — |
Countries
China
Contacts
Public ContactChen Nuoya
Hengshui People's Hospital
Outcome results
None listed