Preeclampsia
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Shihezi University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The normal pregnancy group consisted of naturally conceived singleton pregnancies. The PE group was defined according to the expert consensus in the "Guidelines for the Diagnosis and Treatment of Hypertensive Disorders in Pregnancy (2020)." It includes new-onset hypertension after 20 weeks of gestation (systolic blood pressure >=140 mmHg and/or diastolic blood pressure >=90 mmHg) accompanied by proteinuria (urinary protein quantification >0.3 g/24 h, or urinary protein/creatinine ratio >=0.3, or random urine protein >=(+) [measurement method when protein quantification is not performed]); or no proteinuria but with involvement of any one of the following organs or systems: major organs such as heart, lungs, liver, kidneys, or abnormalities in the hematologic, digestive, or nervous systems, or placental-fetal involvement. Preeclampsia can also occur postpartum.
Exclusion criteria
Exclusion criteria: 1) Fetal genetic abnormalities, chromosomal malformations; 2) Infections such as chorioamnionitis, sepsis, etc.; 3) Harmful physical or chemical exposures during pregnancy; 4) Other diseases related to pregnancy complications (e.g., chronic hypertension and kidney disease); 5) Multiple pregnancies (>=2 fetuses), including cases after multifetal pregnancy reduction or with the death of one fetus;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 14-3-3ß protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Placental 14-3-3ß protein; | — |
Countries
China
Contacts
Public ContactGu Yajuan
The First Affiliated Hospital of Shihezi University
Outcome results
None listed