Postoperative sore throat
Conditions
Interventions
Treatment group (DR group):Treatment group (DR group): 1 µg/kg dexmedetomidine combined with 40 mg of 1% ropivacaine was administered by oropharyngeal spray under video laryngoscopic guidance before t
Ropivacaine group (R group):Ropivacaine group (R group): 40 mg of 1% ropivacaine was administered by oropharyngeal spray under video laryngoscopic guidance before tracheal intubation, targeting the su
Placebo control group (S group):An equal volume of 0.9% normal saline was administered by oropharyngeal spray under video laryngoscopic guidance before tracheal intubation, targeting the supraglottic,
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years; 2. ASA physical status I–III; 3. Scheduled for elective thoracic surgery requiring left-sided double-lumen endotracheal intubation to achieve one-lung ventilation; 4. Able to communicate sufficiently in Chinese and clearly understand the relevant assessment scales; 5. Willing to participate in this study and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. BMI > 30 kg/m²; 2. Patients with a history of sore throat or hoarseness, recent upper respiratory tract infection, prior tracheostomy, Mallampati classification = 3, known or predicted difficult airway, Cormack–Lehane grade III or IV laryngoscopic view, or more than two intubation attempts; 3. Patients with an operative time longer than 3 hours or who are unable to be extubated postoperatively; 4. Patients with allergy to amide local anesthetics, bradycardia, cardiac conduction block, sick sinus syndrome, severe hepatic or renal insufficiency, uncontrolled hypertension, or long-term use of sedative medications such as benzodiazepines, barbiturates, or other sedative-hypnotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sore throat at 24 hours after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of sore throat at 1 hour after extubation;Incidence and severity of sore throat at 6 hour after extubation;Incidence and severity of sore throat at 48 hour after extubation; Severity of sore throat at 24 hours after extubation;Incidence and severity of hoarseness at 1 hour after extubation;Incidence and severity of hoarseness at 6 hour after extubation;Incidence and severity of hoarseness at 24 hour after extubation;Incidence and severity of hoarseness at 48 hour after extubation;Cough score during extubation;Hemodynamic variables during intubation and extubation; | — |
Countries
China
Contacts
Public ContactGuiying Yang
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed