Chronic pain
Conditions
Interventions
Esketamine Group:Esketamine group was injected with Esketamine 0.2 mg/kg by pump (diluted to 20ml with normal saline and pumped for 30min).
Saline Group:20ml of saline and pumped for 30min
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adults over 18 and under 65. 2. Orthopedic patients with moderate and severe pain after elective surgery. 3. Clear consciousness, no mental abnormality, primary school education or above, and can independently and accurately complete the evaluation of the scale in the experiment. 4. Patients with ASA grade I-II 5. Anxiety and depression patients with hospital anxiety and depression scale > 7.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to the active ingredients of Esketamine or all auxiliary materials. 2. Patients with blood pressure or serious risk of increased intracranial pressure. 3. Patients with poorly controlled or untreated hypertension 4. Untreated or under-treated patients with hyperthyroidism. 5. Patients with ischemic heart disease or arrhythmia. 6. Patients who have or have had a history of mental disorders 7. Patients with glaucoma or other diseases that can't bear the increase of intraocular pressure. 8. Patients with severe liver and renal insufficiency 9. Pregnant and lactating patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute postoperative pain;Postoperative anxiety and depression;General data;Vital signs and general monitoring indicators;Assessment of restlessness after tracheal tube removal;Postoperative recovery quality assessment;Postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactHuang Changsheng
Xiangya Hospital, Central South University
Outcome results
None listed