Obesity
Conditions
Interventions
TBW group (Total body weight group):The induction dose of remimazolam is 0.2 mg/kg based on total body weight, administered intravenously over a period of more than 30 seconds.
LBW group (Lean Body Weight group):The induction dose of remimazolam is 0.2 mg/kg based on lean body weight, administered intravenously over a period of more than 30 seconds.
IBW group (Ideal Body Weight group):The induction dose of remimazolam is 0.2 mg/kg based on ideal body weight, administered intravenously over a period of more than 30 seconds.
ABW group (Adjusted Body Weight group):The induction dose of remimazolam is 0.2 mg/kg based on adjusted body weight, administered intravenously over a period of more than 30 seconds.
Sponsors
The Affiliated Cancer Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–65 years; 2.American Society of Anesthesiologists (ASA) Physical Status I–III; 3.Body mass index (BMI) = 28 kg/m².
Exclusion criteria
Exclusion criteria: 1.Known allergy to benzodiazepines or any of their excipients; 2. Difficult airway; 3.Long-term use of sedative-hypnotics or opioids; 4.Pregnancy or lactation; 5.Psychiatric or neurological disorders that preclude cooperation with the assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure before anesthesia induction;Diastolic blood pressure before anesthesia induction;Mean arterial pressure before anesthesia induction;Heart rate before anesthesia induction;The correlation between the weight parameters used during sedation and BMI.;The postoperative recovery indicators were evaluated using the QoR-15 assessment questionnaire within 24 hours.;Motor response;Injection pain;Systolic blood pressure at loss of consciousness;Diastolic blood pressure at loss of consciousness;Mean arterial pressure at loss of consciousness;Heart rate at loss of consciousness;Systolic blood pressure during gastroscope insertion;Diastolic blood pressure during gastroscope insertion;Mean arterial pressure during gastroscope insertion;Heart rate during gastroscope insertion;Systolic blood pressure at 1 minute after gastroscope insertion;Diastolic blood pressure at 1 minute after gastroscope insertion;Mean arterial pressure at 1 minute after gastroscope insertion;Heart rate at 1 minute after gastroscope insertion;Systolic blood pressure at 3 minutes after gastroscope insertion;Diastolic blood pressure at 3 minutes after gastroscope insertion;Mean arterial pressure at 3 minutes after gastroscope insertion;Heart rate at 3 minutes after gastroscope insertion;Incidence of hypoxemia;Incidence of apnea;Anesthesia induction time;Total sedation time;Time to full alertness;Operation duration;Time to discharge after anesthesia;Patient satisfaction with the operation;Endoscopist satisfaction with the operation; | — |
Countries
China
Contacts
Public ContactWang Yue, Meng Fufen
The Affiliated Cancer Hospital of Xinjiang Medical University
Outcome results
None listed