Chronic cough
Conditions
Interventions
Gold Standard:The diagnostic approach for chronic cough is primarily rooted in an exclusionary framework, supplemented by disease-specific investigations to achieve a definitive diagnosis. According t
Index test:Exhaled volatile organic compounds detection using e-nose technology.
Sponsors
ShanghaiTongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. Cough is the sole or primary symptom, with a disease course > 8 weeks; 3. No significant abnormalities on chest CT; 4. FEV1/FVC > 70%, and the percentage of predicted FEV1 > 80%.
Exclusion criteria
Exclusion criteria: 1.Currently smoking or quit smoking for less than 2 years; 2. Pregnant or lactating; 3. History of acute upper respiratory infection within 8 weeks; 4. Oral or inhaled glucocorticoids within 4 weeks; 5. Severe heart failure, severe liver/kidney dysfunction, mental/cognitive impairment, or hearing/communication disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| exhaled VOCs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=2 times;Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=5 times;EOS% in induced sputum;acid exposure time;symptom association probability;Sensitivity ;Specificity; | — |
Countries
China
Contacts
Public ContactYu Li
Shanghai Tongji Hospital
Outcome results
None listed