Intracranial Teratoma Growth Syndrome in children is characterized by germ cell tumor patients showing normal or decreasing tumor marker levels during or after radiochemotherapy, while experiencing rapid tumor volume growth predominantly composed of mature teratoma components.
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Fujian Provincial Children's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with intracranial germ cell tumors; 2.With complete clinical data (imaging, pathological reports, follow-up records, etc.); 3.Patients with preserved paraffin-embedded tumor tissue samples;
Exclusion criteria
Exclusion criteria: 1.Patients with pure germinoma; 2.With concomitant other central nervous system tumors; 3.Patients whom the researchers deem unsuitable for the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether teratoma growth syndrome occurs and the occurrence time;Genomic methylation pattern; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Treatment methods;Initial diagnosis pathological type;Gender;Tumor markers;Tumor location;Imaging features; | — |
Countries
China
Contacts
Public ContactJing Junjie
Fujian Provincial Children's Hospital
Outcome results
None listed