Elderly patients
Conditions
Interventions
Ciprofol Group:Induction: Ciprofol 0.3 mg/kg intravenous bolus
Maintenance: Ciprofol 0.8-1.2 mg/kg/h intravenous infusion
Adjunctive medications: Sufentanil 0.5-1.0 ug/kg, Cisatracurium 0.1-0.15 mg/kg, Remifentanil 0.05-0.2 ug/kg/min
Propofol Group:Induction: Propofol 1.5 mg/kg intravenous bolus
Maintenance: Propofol 4-6 mg/kg/h intravenous infusion
Sponsors
Nanjing Jiangning Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Surgical patients undergoing elective surgery under general anesthesia, both male and female, with American Society of Anesthesiologists (ASA) physical status I to III, aged 60 to 79 years; 2. with normal mental and cognitive function; 3. and no contraindications to anesthetic medications.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiopulmonary dysfunction or hepatic/renal insufficiency, unconsciousness, or inability to cooperate with procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Recovery Score;Serum C-reactive protein (CRP) level;Serum interleukin-6 (IL-6) level;Pittsburgh Sleep Quality Index (PSQI); | — |
Countries
China
Contacts
Public ContactChen Hao
Nanjing Jiangning Hospital
Outcome results
None listed