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Exploration of the minimum effective dose (ED90) of alfentanil in pediatric day-case laparoscopic high ligation of hernial sac under balanced anesthesia.

Exploration of the minimum effective dose (ED90) of alfentanil in pediatric day-case laparoscopic high ligation of hernial sac under balanced anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124280
Enrollment
Unknown
Registered
2026-05-09
Start date
2026-05-09
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric inguinal hernia

Interventions

Single-arm sequential dose exploration (conducted independently by age stratum):Exploration of the minimum effective dose (ED90) of alfentanil in pediatric day-case laparoscopic high ligation of the h

Sponsors

Children’s Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1.Aged 1–6 years, both males and females; 2.BMI-for-age between the 10th and 85th percentiles; 3.Body weight 10–30 kg; 4.Undergoing elective laparoscopic high ligation of the hernial sac; 5.ASA physical status I–II.

Exclusion criteria

Exclusion criteria: 1.History of prematurity; 2.Comorbid congenital heart disease, respiratory disease, metabolic disease, or history of epilepsy; 3.Abnormal liver or kidney function; 4.Preoperative use of opioids; 5.History of allergy to opioids.

Design outcomes

Primary

MeasureTime frame
Satisfactory intubation conditions;No significant body movement within the intubation evaluation window + hemodynamically stable;No significant body movement + hemodynamically stable within the evaluation window for first puncture/cannula placement and pneumoperitoneum establishment;Rescue analgesia or modification of the analgesic regimen;—

Secondary

MeasureTime frame
Spontaneous breathing recovery time;Time to extubation;PACU length of stay;Time to achieve discharge readiness or Time until eligible for discharge.;Maximum FLACC score during the PACU period;Incidence of rescue analgesia;incidence of PONV;Incidence of emergence agitation;Recovery time of orientation/awakening;—

Countries

China

Contacts

Public ContactZhenzhen Tu

Children’s Hospital of Chongqing Medical University

tuzhenzhen@hospital.cqmu.edu.cn+86 150 2305 3503

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026