pain
Conditions
Interventions
Experimental group:All subjects received standardized postoperative multimodal analgesia. Additionally, an ultrasound-guided single-shot femoral nerve block (FNB) was performed. In the experimental gr
Control group:All subjects received standardized postoperative multimodal analgesia. Additionally, an ultrasound-guided single-shot femoral nerve block (FNB) was performed. In the control group, the b
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.ASA physical status I-III; 3.BMI < 35 kg/m^2; 4.Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Clear history of IgE-mediated immediate hypersensitivity to amide local anesthetics (e.g., bupivacaine, ropivacaine, lidocaine, etc.); 2.Uncorrected coagulopathy, or current use of anticoagulant/antiplatelet drugs without reaching the safe discontinuation time recommended by corresponding guidelines; 3.Severe cardiac, pulmonary, hepatic, or renal dysfunction (e.g., NYHA class III-IV, severe organic damage such as myocardial infarction, oxygenation index 1.5 mg/dl, requirement for long-term dialysis, etc.); 4.Presence of peripheral neuropathy or chronic opioid use that may confound postoperative neurological assessment; 5.Pregnant or lactating women; 6.Active skin or soft tissue infection at the planned puncture site; 7.Inability to cooperate with pain scoring or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under NRS score curve (AUC) at 12-72 hours after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total opioid consumption during 0–72 hours postoperatively, expressed as morphine milligram equivalents (MME);;Area under the curve (AUC) of movement-evoked pain Numeric Rating Scale (NRS) scores during 12–72 hours postoperatively;Time to first request for rescue analgesia;Patient satisfaction score (0–10);Incidence of adverse events;Quadriceps muscle strength (MMT grade 0–5);Length of hospital stay (days);Incidence of chronic pain at 30 days postoperatively, defined as NRS = 3.; | — |
Countries
China
Contacts
Public ContactWang Qingxiang
The First Affiliated Hospital of Xiamen University
Outcome results
None listed