Duchenne Muscular Dystrophy?Dilated Cardiomyopathy?Arrhythmia
Conditions
Interventions
Gold Standard:Pediatric patients with a genetically confirmed diagnosis of Duchenne muscular dystrophy (DMD).
Index test:Echocardiography?Electrocardiogram?Cardiac Magnetic Resonance Imaging (MRI)?Serum Cardiac Biomarkers?Troponin?Brain Natriuretic Peptide (BNP)?X-ray for Scoliosis?Body Mass Index
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1.Male children diagnosed with DMD through genetic testing. 2.Possession of regular and complete medical follow-up records for at least 2 years from baseline, including serial echocardiography, motor function assessments, and medication records.
Exclusion criteria
Exclusion criteria: 1.Clinical diagnosis of Becker Muscular Dystrophy or other neuromuscular diseases. 2.Severe heart failure (LVEF < 40%) or having undergone heart transplantation at the study baseline. 3.Presence of other congenital or acquired heart diseases that may independently and significantly affect cardiac function assessment. 4.Missing critical follow-up data exceeding 50%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrocardiogram;Cardiac Magnetic Resonance (CMR);Spinal X-ray;Serum Cardiac Markers; | — |
Countries
China
Contacts
Public ContactSiqi Hong
Children's Hospital of Chongqing Medical University
Outcome results
None listed