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Audiological Phenotypes and Multi-Omics Research in Noise-Sensitive Populations

Audiological Phenotypes and Multi-Omics Research in Noise-Sensitive Populations

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124238
Enrollment
Unknown
Registered
2026-05-09
Start date
2025-03-04
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Noise-induced Hearing Loss

Interventions

Observation group:None

Sponsors

Eye & ENT Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-45 years. 2. Noise exposure history. 3. Abnormal pure-tone audiometry (air conduction or bone conduction threshold >= 20 dB HL at any test frequency; hearing loss predominantly observed at 2, 4, 6, and 8 kHz). 4. Normal congenital development of the ear. 5. Voluntary participation in this study with signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Abnormal development of the ear (congenital auricular deformity, external auditory canal deformity). 2. Ear trauma history. 3. Acute or chronic inflammatory disease in middle ear. 4. Benign or malignant ear tumors. 5. Auditory neuropathy. 6. Sudden sensorineural hearing loss. 7. Meniere's disease. 8. Congenital hearing loss. 9. Family history of hearing loss. 10. Other conditions deemed by the investigator to be unsuitable for enrollment.

Design outcomes

Primary

MeasureTime frame
Pure-tone Threshold Test;acoustic immittance;speech recognition score;

Secondary

MeasureTime frame
high-resolution temporal bone CT data;brain MRI data;Tinnitus Handicap Inventory;

Countries

China

Contacts

Public ContactLi Huawei, Sun Shan, Qi Guowei

Eye & ENT Hospital of Fudan University

shansun@fudan.edu.cn+86 189 1778 6102

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026