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Feasibility Study on the Application of Low-Intensity Pulsed Ultrasound Combined with Ultrasound Contrast Agents for Enhancing Endometrial Blood Flow in Infertile Women

Feasibility Study on the Application of Low-Intensity Pulsed Ultrasound Combined with Ultrasound Contrast Agents for Enhancing Endometrial Blood Flow in Infertile Women

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124226
Enrollment
Unknown
Registered
2026-05-09
Start date
2025-06-10
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility or miscarriage caused by endometrial abnormalities

Interventions

Treatment group :The treatment group received LIPUS therapy every day from day 5 to day 9 of the menstrual cycle (frequency 1.5 MHz, intensity 30 mW/cm2, duty cycle 20%, pulse repetition frequency
Control group:The control group received standard care. Endometrial blood flow was assessed using Doppler ultrasound before and after the intervention, and pregnancy outcomes were monitored.

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Females aged 18-40 years. 2.Diagnosed with infertility or recurrent miscarriage due to inadequate endometrial thickness (<7 mm) or poor endometrial blood flow. 3.Agree to participate in the study and sign the informed consent form

Exclusion criteria

Exclusion criteria: 1.Allergy to ultrasound contrast agents 2.Severe uterine or ovarian diseases 3.Pregnant or lactating women 4.Other conditions that make participation in the study unsuitable

Design outcomes

Primary

MeasureTime frame
Endometrial thickness;Ultrasound Color Doppler Flow Resistance Index and Pulsatility Index;Three dimensional ultrasound endometrial volume;VI;

Countries

China

Contacts

Public ContactLitao Sun

Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital

litaosun1971@sina.com+86 139 4603 7056

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026