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The Effect of High-Flow Nasal Cannula Oxygen Therapy on Postoperative Hypoxemia in Elderly Patients at Moderate-to-High Risk of Pulmonary Complications Undergoing Abdominal Surgery Under General Anesthesia: A Randomized Controlled Trial

Effect of High-Flow Nasal Cannula Oxygen Therapy on Postoperative Hypoxemia in Elderly Patients at Moderate-to-High Risk of Pulmonary Complications Undergoing Abdominal Surgery Under General Anesthesia: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124220
Enrollment
Unknown
Registered
2026-05-08
Start date
2026-05-11
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypoxemia

Interventions

Experimental group:After tracheal extubation, the patients received high-flow nasal cannula oxygen therapy (HFNC) with an initial fraction of inspired oxygen (FiO?) of 30%, flow rate of 50 L/min, and
control group:After tracheal extubation, the patients received conventional oxygen therapy at an oxygen flow rate of 2–6 L/min for 30 consecutive minutes.

Sponsors

The First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Elderly patients (>=65 years old) undergoing abdominal surgery under general anesthesia. 2. Preoperative ARISCAT score > 26 (indicating moderate to high risk of postoperative pulmonary complications). 3. Anticipated operative duration of at least 2 hours with intraoperative Trendelenburg position required. 4. Patients or their family members have agreed and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. ASA physical status >= Grade IV. 2. BMI >= 28 kg/m². 3. Obstructive sleep apnea syndrome. 4. Patients with chronic pulmonary diseases requiring oxygen therapy. 5. Patients with mental illness and/or unable to communicate. 6. Patients who refuse to participate in the study. 7. Patients undergoing life-threatening emergency surgery. 9. Patients with tracheotomy or any nasal/facial defects that may interfere with the use of HFNC.

Design outcomes

Primary

MeasureTime frame
Incidence of hypoxemia at 1 hour after extubation;Patient Oxygen Tolerance Score;—

Secondary

MeasureTime frame
Lung Ultrasound Score (LUS) before general anesthesia extubation and at 1 hour after extubation;the lowest SpO? value observed in the Post-Anesthesia Care Unit (PACU) and the frequency of airway rescue interventions.;Length of stay in the Post-Anesthesia Care Unit (PACU);Incidence of Postoperative Pulmonary Complications (PPCs) within 72 hours after surgery;Length of hospital stay;—

Countries

China

Contacts

Public ContactMo Yunchang

The First Affiliated Hospital of Wenzhou Medical University

huangledanzui@sina.com+86 137 3692 4260

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026