Hypertension
Conditions
Interventions
High-dose group:High-dose coix seed powder
Control group:Rice powder
Low-dose group:Low-dose coix seed powder
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
30 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age between 30 and 55 years; 2. Within the past 3 months, systolic blood pressure of 130–159 mmHg and/or diastolic blood pressure of 80–99 mmHg, measured on three different occasions on non-consecutive days; 3. Willing to participate in this study and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary hypertension; 2. Use of antihypertensive medications or other drugs that may directly affect blood pressure within the past 6 months; 3. Pregnant or breastfeeding women, or women planning to become pregnant during the study period; 4. Individuals with allergy to coix seed; 5. Individuals with abnormal glucose metabolism, including impaired glucose tolerance or diabetes mellitus; 6. Patients with serious cardiovascular or cerebrovascular diseases, such as myocardial infarction or unstable angina; 7. Patients with severe hepatic or renal dysfunction, or endocrine disorders such as hyperthyroidism, hypothyroidism, or hypercortisolism; 8. Patients with malignancies or autoimmune diseases; 9. Vulnerable populations, including individuals with mental illness, cognitive impairment, critically ill conditions, or illiteracy; 10. Participation in other clinical studies within the past 3 months; 11. Any other conditions that, in the opinion of the investigators, make the participant unsuitable for inclusion in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition;Blood biochemistry;Blood pressure;Non-targeted metabolomics;Complete blood count;Adverse outcome;Ambulatory blood pressure; | — |
Countries
China
Contacts
Public ContactHui Liu
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed