Chronic liver disease
Conditions
Interventions
Research Group:On the basis of routine liver protection therapy, vitamin D screening was carried out, serum 25 (OH) 3 ? level was detected, and targeted vitamin D supplementation therapy was given acc
control group:Routine liver protection treatment was given, including liver protection drugs (such as polyene phosphatidylcholine, silibinin, etc.), etiological treatment (such as antiviral treatment,
Sponsors
Shifang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old, regardless of gender 2. The diagnosis of chronic liver disease (including chronic hepatitis B, chronic hepatitis C, alcoholic fatty liver, liver cirrhosis compensatory period, etc.) was confirmed by clinical symptoms, signs, liver function examination, imaging examination (ultrasound, CT, etc.) and etiological examination 3. Voluntarily participate in the study and sign the informed consent form 4. Able to cooperate to complete the whole follow-up and various examinations.
Exclusion criteria
Exclusion criteria: 1. Severe liver failure, liver cancer, hepatic encephalopathy and other complications were observed 2 Complicated with severe heart, kidney, lung, endocrine and other system diseases 3 Recently (within 3 months) taking vitamin D supplements, glucocorticoids, immunosuppressants and other drugs that may affect the results of the study 4 Pregnant or lactating women 5 Allergic to vitamin D supplements 6 Mental illness, cognitive impairment and other patients who cannot cooperate with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25 (OH) D3 level;Alanine Aminotransferase (ALT);Aspartate Aminotransferase (AST);Apri score;Liver stiffness value (LSM); | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions, including gastrointestinal discomfort, dizziness, fatigue, rash, etc; | — |
Countries
China
Contacts
Public ContactXianrong Yin
Shifang People's Hospital
Outcome results
None listed