intracranial artery severe stenosis or occlusive acute ischemic stroke
Conditions
Interventions
Interventional therapy group for mild stroke:None
Drug treatment group for mild stroke:None
Moderate-severe stroke:None
Sponsors
Yongchuan Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18 years; 2. The time from the onset of the first stroke symptom to admission is within 72 hours; 3. Judged as acute anterior circulation ischemic stroke based on clinical manifestations and imaging examinations; 4. CTA/MRA/DSA confirmed that the responsible vessel is the C6-7 segment of ICA, M1, M2, A1, A2, A3 with severe stenosis (stenosis rate = 70%, stenosis rate = (1 - D stenosis / D normal) × 100%, where D stenosis refers to the diameter of the most severely stenotic part of the artery, and D normal refers to the diameter of the normal artery at the proximal end of the stenosis); 5. The patient or the patient's family signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Intracranial hemorrhagic diseases confirmed by CT or MRI; 2. midline shift shown by CT or MRI; 3. chronic occlusion or dissection of the responsible vessel confirmed or suspected clinically; 4.mRS = 2 before the onset; 5. pregnant or lactating women; 6.severe renal dysfunction (serum creatinine > 220 µmol/L); 7.iodine contrast agent allergy; 8.high bleeding risk (platelet count 50 seconds or PT-INR > 3.0), or existing coagulation disorders, history of systemic bleeding; 9.severe or fatal comorbidities (hepatic and renal dysfunction, cardiac and pulmonary dysfunction, expected survival time less than 6 months, etc.); 10.the investigator judges that endovascular treatment is not suitable; 11.due to various reasons such as mental disorders, cognitive or emotional disorders, the investigator judges that the subject is likely to have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin scale score 90 days after oneset;Mortality at 90 days after interventional therapy;Other procedure-related complications;The vessel was reoccluded within 7 days after interventional therapy;Symptomatic intracranial hemorrhage (The National Institutes of Health Stroke Scale increase =4) within 48 hours after surgery;Recurrent ischemic stroke within 90 days;the success rate of interventional therapy group;Any intracranial hemorrhage within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| The NIHSS score improved by =4 points within 48 hours after interventional therapy;percentage of patients with a modified Rankin scale score of 0-1 at 90 days after oneset;percentage of patients with a modified Rankin scale score of 0-1 at 90 days after oneset; | — |
Countries
China
Contacts
Public ContactGao xiangjie
Yongchuan Hospital of Chongqing Medical University
Outcome results
None listed