None
Conditions
Interventions
Experimental Group 1:Intravenous anesthesia with oliceridine combined with Etomidate. The dose of Oliceridine is fixed at 10ug/kg, and the initial dose of Etomidate is 0.15 mg/kg. Subsequently, the do
Experimental Group 2:Intravenous anesthesia with oliceridine combined with Etomidate. The dose of Oliceridine is fixed at 15ug/kg, and the initial dose of Etomidate is 0.15 mg/kg. Subsequently, the do
Experimental Group 3:Intravenous anesthesia with oliceridine combined with Etomidate. The dose of Oliceridine is fixed at 20ug/kg, and the initial dose of Etomidate is 0.15 mg/kg. Subsequently, the do
Sponsors
Guanyuan Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 60 - 80 years old. Gender: No restrictions. 2. (BMI): 18 - 30 kg/m^2. 3. American Society of Anesthesiologists (ASA) classification: II - III grade. 4. Patients scheduled for painless gastroscopy and colonoscopy.
Exclusion criteria
Exclusion criteria: 1. Refusal to cooperate with this study; 2. Those with severe complications in organs such as heart, lungs, liver, and kidneys; 3. Those who have been using drugs that may affect the analgesic response for a long time (central a-adrenergic drugs, anticonvulsants, neuroleptics, antidepressants, antipsychotics); 4. Those who are known to be allergic to emulsions, opioid drugs; 5. Obstructive sleep apnea-hypopnea syndrome (OSAHS); 6. Those with acute respiratory inflammation within 2 weeks; 7. Those who cannot cooperate or communicate; 8. Those addicted to opioid drugs or alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body movement response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea and vomiting;Anesthesia Recovery Time;Hypoxemia;Dosage of vasoactive drugs;Blood pressure;Heart rate;Pulse oximetry;Sedation related adverse events;Maintenance time;Effective time; | — |
Countries
China
Contacts
Public ContactFeng Liang
Guanyuan Central Hospital
Outcome results
None listed