High-risk groups for colorectal cancer screening
Conditions
Interventions
the model derivation cohort:None
the implementation cohort:None
Sponsors
Taizhou Cancer Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1.Participants were included in the model derivation cohort if they met the following criteria: (1) Residents of Wenling City who participated in the population-based colorectal cancer screening program between January 1, 2023 and December 31, 2025; (2) Aged 50–74 years at the time of screening registration; (3) Completed quantitative FIT, with results traceable to original laboratory data; (4) Underwent colonoscopy due to a positive FIT result or other clinical indications, with complete colonoscopy reports and histopathological diagnoses available; (5) Held permanent residency in Wenling City, with identifiable information that could be linked to the Zhejiang Colorectal Cancer Screening Information Platform’s cancer registry and household registration databases. 2.Participants were included in the implementation cohort if they met the following criteria: (1) Residents of Wenling City who participated in the population-based colorectal cancer screening program between January 1, 2023 and December 31, 2025; (2) Aged 50–74 years as of the program implementation start date (April 1, 2026); (3) Completed quantitative FIT, with results traceable to original laboratory data; (4) Had a positive FIT result but had not undergone colonoscopy; (5) Held permanent residency in Wenling City, with identifiable information that could be linked to the Zhejiang Colorectal Cancer Screening Information Platform’s cancer registry and household registration databases. (6) All participants provided written informed consent and were determined to have the capacity to understand the study purpose.
Exclusion criteria
Exclusion criteria: 1.Participants were excluded from the model derivation cohort if they met any of the following criteria: (1) with a prior or current diagnosis of colorectal cancer, inflammatory bowel disease (ulcerative colitis, Crohn’s disease), or hereditary colorectal cancer syndromes (e.g., Lynch syndrome, familial adenomatous polyposis); (2) with a history of colorectal resection due to the aforementioned conditions, or currently undergoing treatment for colorectal cancer; (3) with incomplete colonoscopy (cecal intubation not achieved) or inadequate bowel preparation (Boston Bowel Preparation Scale score 6 months for migrant work) during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of the risk stratification model for colorectal cancer in island populations;Colonoscopy adherence rate, Advanced neoplasia yield; | — |
Secondary
| Measure | Time frame |
|---|---|
| Screening uptake rate and Early diagnosis rate; | — |
Countries
China
Contacts
Public ContactHaipeng Jin
Taizhou Cancer Hospital
Outcome results
None listed