Autoimmune epilepsy
Conditions
Interventions
acute symptomatic seizures secondary to autoimmune encephalitis(ASSAE) group:No
autoimmune-associated epilepsy(AAE) group:No
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ?Meeting the ILAE (2017) diagnostic criteria for epilepsy, with epilepsy being the sole or primary clinical manifestation ? 2. ?Cerebrospinal fluid (CSF) biochemical analysis showing inflammatory changes 3. ?Serum or cerebrospinal fluid (CSF) testing for anti-neuronal autoantibodies.?
Exclusion criteria
Exclusion criteria: 1. ?The epilepsy is clearly caused by etiologies other than immune factors, such as genetic factors, structural abnormalities, metabolic disorders, infections, or tumors 2. ?The presence of other systemic diseases, such as hypertension, endocrine disorders, cardiovascular diseases, hepatic or renal dysfunction, diabetes mellitus, intestinal diseases, or chronic diarrhea and constipation ? 3. ?Use of any antibiotics or probiotic preparations during the follow-up period, or consumption of yogurt as part of the diet? 4. ?Pregnant or lactating women, individuals with a history of psychiatric disorders, or those unable to comply with the study procedures.?
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NMDAR antibodies;LGI1 protein antibodies;CSF WBC count(×10?/L);MOG antibodies;CSF IgG index;GABA-A/BR antibodies;VEEG;CSF total protein concentration ( mg/dL or g/L)?;GAD65 antibodies;CSF oligoclonal bands;Serum immunoglobulin quantification; | — |
Countries
China
Contacts
Public ContactJiang Yan
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed