None
Conditions
Interventions
Control group:Simple bupivacaine for Intrathecal anesthesia
5ug sufentanil group:5ug sufentanil combined with bupivacaine for Intrathecal anesthesia
10ug sufentanil group:10ug sufentanil combined with bupivacaine for Intrathecal anesthesia
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients classified as ASA II; 2. Women with a single full-term pregnancy awaiting labor; 3. Individuals with no history of drug allergies or drug abuse; 4. Those who have signed the informed consent for combined spinal-epidural anesthesia.
Exclusion criteria
Exclusion criteria: 1. Pregnant women with pregnancy-induced hypertension, mild preeclampsia, severe preeclampsia, eclampsia, or hypotension; 2. Those with diabetes with pregnancy, gestational diabetes, pregnancy complicated with heart disease, or viral hepatitis; 3. Patients with a body mass index (BMI) >28 kg/m^2, excessively obese patients; 4. Pregnant women with coagulation disorders, respiratory diseases, contraindications to spinal anesthesia, preoperative medication use, mental disorders, or a history of opioid abuse; 5. Cases where fetal growth restriction, macrosomia, placenta previa, placental abruption, or premature rupture of membranes leads to fetal distress or stillbirth; 6. Pregnant women for whom anesthesia puncture fails or who do not cooperate during the procedure; 7. Those with spinal deformities or allergy to local anesthetics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective dose and 95% effective dose of bupivacaine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs of pregnant women (SBP, DBP, MAP, HR, SPO2) at corresponding time points;The incidence of adverse maternal events during the perioperative period (including but not limited to hypotension, hypertension; bradycardia, tachycardia; pruritus; dyspnea; chest tightness; pulling discomfort; nausea and vomiting; chills);1-minute and 5-minute Apgar scores of newborns;The occurrence time and recovery time of the movement-blocking sensation in pregnant women; | — |
Countries
China
Contacts
Public ContactGuo Yanxia
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed