gestational diabetes mellitus
Conditions
Interventions
Getational Diabets Mellitus group:None
Healthy control group:None
Sponsors
Sichuan Provincial Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancy; 2. Aged 20–40 years; 3. Gestational age < 30 weeks at enrollment; 4. Registered medical records at the recruiting hospital with a plan to undergo regular antenatal care and delivery at the same institution; 5. Completed 75g Oral Glucose Tolerance Test (OGTT) between gestational weeks 24–28; 6. Willingness to comply with the study protocol and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing diabetes mellitus diagnosed prior to pregnancy; 2. Overt diabetes during pregnancy: Fasting plasma glucose =7.0 mmol/L, random plasma glucose =11.1 mmol/L, or HbA1c =6.5%; 3. Infectious or inflammatory conditions: Periodontitis, gingivitis, oral infections, acute gastroenteritis, inflammatory bowel disease, or other oral/gastrointestinal disorders within the past 3 months; 4. Medication interference: Use of antibiotics, probiotics, prebiotics, glucocorticoids, immunosuppressants, or other agents affecting microbiota within the past 1 month; 5. Comorbidities: Gestational hypertension, preeclampsia, thyroid disorders, autoimmune diseases, severe hepatic or renal dysfunction, malignant tumors, or other serious medical conditions; 6. Multiple or abnormal pregnancies: Multiple gestation, threatened abortion, fetal developmental abnormalities, or other conditions contraindicating study participation; 7. History of glucose metabolism disorders: Polycystic ovary syndrome (PCOS), Cushing's syndrome, or other conditions affecting blood glucose regulation; 8. Infectious diseases: Hepatitis B, Hepatitis C, HIV/AIDS, syphilis, or other communicable diseases; 9. Maternal lifestyle factors: Smoking or alcohol consumption during pregnancy; 10. Poor compliance or incomplete data: Inability to cooperate with sample collection/questionnaire completion, incomplete clinical documentation, or voluntary withdrawal from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alpha and beta diversity, community structure, functional divergence, and keystone taxa of oral, vaginal, gut, and placental microbiota across four body sites.; | — |
Secondary
| Measure | Time frame |
|---|---|
| glycemic excursion; | — |
Countries
China
Contacts
Public ContactGao Yan
Sichuan Provincial Maternity and Child Health Care Hospital
Outcome results
None listed