Thoracolumbar compression fracture
Conditions
Interventions
Intervention group:oliceridine combined with remimazolam (intervention group): Intravenously inject 1mg of orselenide when turning over
at the beginning of surgery, slowly inject 0.05mg/kg of remazolam intravenously, and then continuously pump 0.1mg/kg/h of remazolam intravenously
Control group:Conventional local anesthesia group (control group): At the same time point, administer an equal dose of placebo (physiological saline) via intravenous injection and pump infusion
Sponsors
Peking University People’s Hospital, Qingdao
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age between 65 and 85 years old, gender not limited; 2. ASA Classification II~III; 3. Body Mass Index (BMI) 18~28 kg/m^2; 4. Frail scale frailty score >= 3 points; 5. Complies with the indications for percutaneous vertebroplasty; 6. Thoracolumbar compression fracture; 7. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Concurrent pulmonary infection; 2. History of allergy to relevant anesthetic drugs; 3. Mental illness or cognitive dysfunction; 4. Hepatic and renal insufficiency; 5. Long-term use of sedative or analgesic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;Doctor satisfaction;Patient satisfaction;Incidence of intraoperative adverse events ; | — |
Countries
China
Contacts
Public ContactXu Zhang
Peking University People’s Hospital, Qingdao
Outcome results
None listed