Depression
Conditions
Interventions
The taVNS group:Place the stimulating electrodes on the left auricle area. Perform the intervention twice a day, each session lasting 30 minutes, for a total of 4 weeks. The stimulation parameters are
Sham taVNS group:Using the sham stimulation mode (a special driving mode, where the subject experiences a sensation similar to taVNS, but without any actual stimulation of the vagus nerve)
Control group:None
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for major depressive disorder as stipulated in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 2. First onset without medication; 3. Age ranging from 18 to 55 years old; 4. Total score of the HAMD scale (17 items) ranging from 8 to 24 points; 5. Right-handed; 6. Voluntarily participated in this study and signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from other mental disorders; 2. Having other physical diseases, especially gastrointestinal diseases; 3. Those with a severe tendency towards suicide; 4. Those with evidence of alcohol or other substance dependence or abuse; 5. Family history: Family history of mental disorders such as bipolar disorder and schizophrenia; 6. Treatment history: Have received treatment with antibiotics, probiotics, immunosuppressants, etc. within the last 1 month; 7. Reproductive history: Pregnant or lactating women; 8. Have participated in a clinical trial within the past 90 days or have participated in 2 or more clinical trials within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The decrement value and decrement rate of the HAMD17 score; | — |
Countries
China
Contacts
Public ContactSun Ning
The First Hospital of Shanxi Medical University
Outcome results
None listed