Postoperative pain and recovery quality
Conditions
Interventions
Experimental group:The experimental group (fixed-dose group) received a total dose of 100 µg of sufentanil through PCIA.
Control group:The control group (based on the body weight group) received a total dose of 2 µg/kg of sufentanil for PCIA.
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, ASA physical status ?-?, scheduled for thoracoscopic lung surgery in the afternoon; 2. No history of long-term use of opioids, non-steroidal anti-inflammatory drugs or sedative and hypnotic drugs; 3. Clear consciousness, can cooperate to complete the NRS pain score and postoperative follow-up; 4.BMI 18.5-30kg/m², weight 50-75kg, no history of obstructive ventilation disorder, no history of severe pulmonary disease; 5. The operation was performed by the same group of surgeons to ensure the consistency of operation and postoperative management.
Exclusion criteria
Exclusion criteria: 1. Severe cardiopulmonary dysfunction (acute exacerbation of COPD, NYHA class ?-? heart failure, ventricular tachycardia, frequent ventricular premature, uncontrolled atrial fibrillation), liver and kidney dysfunction (Child-Pugh class B-C, serum creatinine > 133µmol/L or GFR<60ml/min), and coagulation abnormalities; 2. Patients with a history of opioid or non-steroidal drug allergy and bronchial asthma; 3. Taking antidepressants/anxiolytic drugs for a long time before surgery, or having cognitive impairment or severe audio-visual impairment; 4. Intraoperative conversion to thoracotomy; 5. Patients with severe bradycardia (heart rate < 50 beats/min) or heart block; 6. Participate in other clinical studies simultaneously.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting pain score;Activity/Cough/Pain Score;The maximum pain score perceived;Analgesic effect: Total dosage of sufentanil, number of patient-controlled analgesia presses, and usage of rescue analgesic drugs;The incidence rate of adverse reactions related to opioid drugs (such as nausea, vomiting, dizziness, skin itching, urinary retention, difficulty in defecation, etc.);Patient recovery quality;Whole blood cell-derived inflammatory markers;Patients' general conditions and surgical anesthesia process were compared, such as the duration of surgical anesthesia and the amount of analgesic drugs used; | — |
Countries
China
Contacts
Public ContactSizhe Feng;Xiangqing Xiong
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed