Parkinson's disease
Conditions
Interventions
Treatment group:Brain-computer interface training equipment (LSR-A? BCI Rehabilitation Training System) combined with functional electrical stimulation therapy: 20 min/day for the upper extremities an
Control group:Functional electrical stimulation therapy: 20 min/day for the upper extremities and 20 min/day for the lower extremities, for a total of 12 treatment days within two weeks.
Sponsors
Binzhou Medical University Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 40–80 years, male or female; 2.Meet the diagnostic criteria for Parkinson’s disease formulated by the United Kingdom Parkinson’s Disease Society Brain Bank and the Movement Disorder Society (MDS) in 2015; 3.Have received stable doses of levodopa and benserazide tablets, dopamine receptor agonists, or monoamine oxidase type B inhibitors for one month prior to study enrollment; 4.Subjects and their family members understand the clinical trial protocol, volunteer to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Various secondary Parkinsonian syndromes, Parkinson-plus syndromes, and other non-primary Parkinson's disease (PD); 2.Presence of intracranial metal implants, cardiac pacemakers, or incomplete skull; 3.Skin lesions, damage, infection at the electrode contact sites, or allergies to electrodes; 4.History of stroke or thrombosis within one year; 5.Severe cognitive impairment or comorbidity with other serious mental disorders, resulting in inability to comply with the study protocol; 6.Other conditions deemed inappropriate for enrollment by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mds unified-parkinson disease rating scale-?; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fractional Anisotropy,Mean Diffusivity;Glutamate;Diffusion Tensor Imaging Analysis along the Perivascular Space; Amplitude of Low-Frequency Fluctuation, Regional Homogeneity;The Non-Motor Symptoms Scale for Parkinson’s Disease;Pittsburgh Sleep Quality Index score;Hoehn-Yahr;Montreal Cognitive Assessment score;Parkinson's Disease Questionnaire-39;Parkinson's Disease Sleep Scale-2 score;Hamilton Anxiety Rating Scale score;Hamilton Depression Rating Scale-17 score;Fatigue Scale-14 score;Autonomic Nervous System Symptom Self-Rating Scale score;Patient Assessment of Constipation-Symptoms score; | — |
Countries
China
Contacts
Public ContactHongcai Wang
Binzhou Medical University Hospital
Outcome results
None listed