chronic renal failure
Conditions
Interventions
LIBS Real-time Monitoring Group:The calcium supplementation infusion rate is automatically calculated and updated in real time based on monitoring data from the LIBS system, and adjusted according to
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 80 years, with no gender restriction. 2.Diagnosed with chronic renal failure and requiring regular intermittent hemodialysis (IHD) or sustained low-efficiency dialysis (SLED). The dialysis modality (maintenance hemodialysis [HD], hemodiafiltration [HDF], or SLED) is determined by routine clinical practice. Dialysate flow rate, blood flow rate, and treatment duration are implemented in accordance with clinical standards. 3.The patient is judged by the investigator to have a stable vascular access with a blood flow rate = 200 mL/min. 4.Voluntarily participates in this study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Received citrate-containing drugs or preparations within 72 hours prior to enrollment, or anticipated to require blood transfusion during the trial. 2.Requires supplementary calcium therapy outside the study protocol during intermittent hemodialysis (IHD). 3.Baseline ionized calcium concentration 1.35 mmol/L. 4.Hypersensitivity to extracorporeal circuit tubing, dialysate, citrate, or calcium-containing solutions. 5.Complicated with active malignant tumor, severe infection, or liver failure. 6.Pregnant or lactating women. 7.Predicted survival time of less than 72 hours. 8.Participated in other clinical trials within 3 months prior to signing the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total calcium, dialysate effluent; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematocrit;Potassium;Sodium;pH;Bicarbonate;Base excess;Total calcium, arterial;Ionized calcium, arterial;Ionized calcium, post-filter;Citrate concentration, arterial; | — |
Countries
China
Contacts
Public ContactDING FENG
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed