Mild cognitive impairment
Conditions
Interventions
Control group:After enrollment, participants will receive health education on dementia prevention. During the trial, registered dietitians will provide only healthful dietary education to the particip
Anti-inflammatory diet group:Based on participants' self-reported dietary patterns at baseline, two registered dietitians from our institution will develop individualized anti-inflammatory dietary pla
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
60 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Permanent community residents aged 60–69 years with no plans for relocation or long-term absence within one year; 2. A Montreal Cognitive Assessment (MoCA) score >=19 and =12 years of education, or a score >=18 and 0 or meeting the criteria for a pro-inflammatory diet; 4. Ability to participate in study-related intervention activities, either independently or with assistance from family members.
Exclusion criteria
Exclusion criteria: 1. Those diagnosed with dementia or suspected dementia; 2. History of traumatic brain injury; 3. Active infection or inflammatory diseases (e.g., autoimmune diseases); 4. Severe physical and/or mental illnesses (e.g., severe cardiac, hepatic, renal, or respiratory diseases, Parkinson's disease, or conditions deemed by a specialist physician as precluding participation in the intervention); 5. Currently undergoing cognitive training or participating in other interventional studies; 6. Another member of the same household has already been enrolled; 7. Use of antibiotics, probiotics, prebiotics, or synbiotics within three months prior to recruitment; 8. Allergy history to two or more of the following: legumes, fish, fruits, nuts; 9. Severe hearing, visual, or speech impairments, or other conditions that would affect study assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation;Biomarkers of Aß accumulation;Biomarkers of Tau pathology;Biomarkers of neuronal degeneration or injury;Biomarkers of neuroinflammation;Intestinal flora;Metabonomics; | — |
Countries
China
Contacts
Public ContactGuo Jie
China Agricultural University
Outcome results
None listed