Hip replacement surgery
Conditions
Interventions
Esketamine Group:Anesthesia induction begins with a constant-rate pump infusion of esketamine (50 mg diluted to 50 ml) at a dose of 0.3 mg/kg, infused over 15 minutes
after the esketamine loading dose infusion is completed, it is switched to a continuous pump infusion at 0.3 mg/(kg·h).
Blank control group:Start the anesthesia induction by continuously pumping an equal amount of saline, with an infusion time of 15 minutes
after the loading dose is completed, switch to a continuous infusion of saline, with parameters consistent with those in group E.
Sponsors
Central Theater Command General Hospital of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65–90 years, ASA classification II–III, BMI = 30 kg/m^2; 2. Patients undergoing hip replacement surgery under general anesthesia; 3. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Preoperative existing untreated lung diseases, including lung infections, moderate to severe chronic obstructive pulmonary disease (COPD, GOLD grade 2 or above, see Table 2.1), acute exacerbation, respiratory failure, ARDS, or pulmonary hypertension; 2. Preoperative low oxygen saturation (SpO2 < 90%) or concurrent systemic infection; 3. Untreated or poorly controlled hypertension or diabetes; 4. Presence of immune system diseases or long-term use of glucocorticoid medications; 5. Serious cardiovascular adverse events within 6 months before surgery, including angina, severe arrhythmia, myocardial infarction, as well as transient ischemic attack or stroke; 6. Severe liver or kidney dysfunction; 7. Cognitive impairment or mental illness; 8. Contraindications to esketamine use (such as pyloric obstruction, concurrent intracranial hypertension, increased intraocular pressure, untreated or inadequately treated hyperthyroidism, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FEV1% pred;Postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactLi Bixi
Chinese People's Liberation Army Central Theater Command General Hospital
Outcome results
None listed