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Study on How Changes in Nasal Bacteria and Phenylalanine Metabolism Affect Smell Loss Caused by Air Pollutant Benzo[a]pyrene

Study on How Changes in Nasal Bacteria and Phenylalanine Metabolism Affect Smell Loss Caused by Air Pollutant Benzo[a]pyrene

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124129
Enrollment
Unknown
Registered
2026-05-07
Start date
2026-05-08
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

healthy control group:None

Sponsors

Shanxi Medical University First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1: Patients with newly diagnosed primary Parkinson's disease (PD) diagnosed by a neurologist at the attending physician level or above, according to the 'Chinese Parkinson's Disease Diagnostic Guidelines' (2016 edition); 2: Hoehn-Yahr (H-Y) stage of 1.0-2.0; 3: aged between 50 and 80 years; 4: have signed the informed consent and are able to cooperate in completing medical history collection, olfactory function assessment, and biological sample collection.

Exclusion criteria

Exclusion criteria: 1: Patients with secondary PD caused by drugs, toxins, traumatic brain injury, or cerebrovascular disease 2: individuals with primary olfactory disorders 3: those with oral, pharyngeal, or nasal diseases that may cause olfactory dysfunction 4: those with a history of respiratory infection in the past two weeks 5: idividuals with cognitive or motor impairments 6: patients with liver, kidney, lung, or other visceral dysfunction 7: those with a family history of neurological diseases 8: and patients unable to cooperate with medical history collection, assessment, or biological sample collection.

Design outcomes

Primary

MeasureTime frame
Benzo[a]pyrene;

Countries

China

Contacts

Public ContactQiuyan Wang

Shanxi Medical University First Hospital

wqiuyanwangqy@sina.com+86 159 3515 8915

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026