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Application of brain-computer interface technology combined with transcranial direct current stimulation in disorders of consciousness

Application of brain-computer interface technology combined with transcranial direct current stimulation in disorders of consciousness

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124127
Enrollment
Unknown
Registered
2026-05-07
Start date
2024-07-20
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of consciousness

Interventions

Control group(VS patients):Common rehabilitation
tDCS group(VS patients):Common rehabilitation+transcranial direct current stimulation
SON group(VS patients):Common rehabilitation+stimulation of name
SON+tDCS group(VS patients):Common rehabilitation+stimulation of name+transcranial direct current stimulation
Control group(MCS patients):Common rehabilitation
tDCS group(MCS patients):Common rehabilitation+transcranial direct current stimulation
AV group(MCS patients):Common rehabilitation+audio-visual stimulation
AV+tDCS group(MCS patients):Common rehabilitation+audio-visual stimulation+transcranial direct current stimulation

Sponsors

Affiliated Hospital of Nantong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for disorders of consciousness; 2. Ages between 18 and 80; 3. Impairment of consciousness due to various causes such as traumatic or non-traumatic; 4. Duration > 28 days; 5. The Coma Recovery Scale-Revised (CRS-R) was assessed as vegetative state(VS) or minimally conscious state(MCS); 6. Vital signs stable; 7. Informed consent of subjects and their families was obtained.

Exclusion criteria

Exclusion criteria: 1. A history of neurological or psychiatric problems; 2. Presence of metal implants or implanted electronic brain medical devices (e.g. pacemakers); 3. A history of cranioplasty of an unhealed skull flap, or severe scalp trauma that prevents electrodes from being placed or may result in infection by examination; 4. Sedatives should be administered within 24 hours; 5. Hearing impairment; 6. Patients with unstable vital signs or impaired functions of multiple systems and organs; 7. Previous treatment with transcranial electrical or transcranial magnetic stimulation.

Design outcomes

Primary

MeasureTime frame
Coma Recovery Scale-revised(CRS-R);—

Secondary

MeasureTime frame
Stockholm CT score;Magnetic resonance spectroscopy (MRS);Blood oxygen level dependent functional magnetic resonance imaging;Diffusion tensor Imaging(DTI);Event-related potential (MMN/P300);Electroencephalogram characteristics;Disability Rating Scale(DRS);Glasgow Outcome Scale(GOS);—

Countries

China

Contacts

Public ContactSu Liu

Affiliated Hospital of Nantong University

327202278@qq.com+86 513 8116 8128

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026