Perioperative pain / intraoperative nociceptive response
Conditions
Interventions
Sufentanil alone group:None
The sufentanil + butorphanol group:None
The sufentanil + morphine/oxycodone group:None
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18–80 years, regardless of sex. 2.Patients scheduled for elective surgery under general anesthesia with planned intraoperative use of sufentanil. 3. American Society of Anesthesiologists (ASA) physical status I–III. 4.Written informed consent provided voluntarily.
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to any opioid drugs involved in this study. 2.Severe hepatic dysfunction (Child-Pugh class C) or renal failure requiring dialysis before surgery. 3.Long-term preoperative opioid use or history of substance abuse. 4.Pregnant or lactating women. 5.Any other condition judged by investigators to make the patient unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Population pharmacokinetic parameters of sufentanil; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic response indicators; | — |
Countries
China
Contacts
Public ContactHanjing
Zhongshan Hospital, Fudan University
Outcome results
None listed