Orthopedic lower limb diseases
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Orthopedic lower limb surgery patients aged 18 to 65; 2. American Society of Anesthesiologists (ASA) classification I to III; 3. Patients have signed informed consent; 4. Anesthesia method is combined spinal-epidural anesthesia.
Exclusion criteria
Exclusion criteria: 1. History of severe mental illness; 2. Severe organic lesions of important organs; 3. Allergy to the anesthetic drugs being used; 4. Recent use of drugs that affect mental perception or pain sensation; 5. Patients with sensory or pain perception disorders at the measurement site; 6. Patients unable to communicate normally; 7. Patient refusal; 8. Drug abuse or addiction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| SAS anxiety score;Hemodynamic indicators;length of hospital stay;TNF-a;IL-6;PGE;ß - endorphin;cortisol;First time getting out of bed after surgery;VAS score;Sedation and agitation score;Postoperative salvage analgesia time (from the end of surgery to the first administration of analgesic medication in the ward);Medication situation for remedial analgesia; | — |
Countries
China
Contacts
Chuanbei Medical College Affiliated Hospital