None
Conditions
Interventions
Group R : Remazolam:Patients randomised to group R were given remazolam 0.25mg/kg for induction of anaesthesia
Group E : Etomidate:Patients randomised to group E were given etomidate 0.2mg/kg for induction of anaesthesia.
Sponsors
Beijing Tsinghua Changgung Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years 2. Intended elective surgery under combined intravenous-inhalation anesthesia 3. Intended use of a single-lumen endotracheal tube 4. Voluntary participation with signed informed consent
Exclusion criteria
Exclusion criteria: 1. Cognitive dysfunction or neuropsychiatric disorders. 2. Patients with confirmed or suspected abuse of, or long-term use of, narcotic sedatives/analgesics, hypnotics, or antidepressants. 3. Patients with contraindications or hypersensitivity/allergy to the study drugs, including benzodiazepines, etomidate, rocuronium, or any of their components. 4. Anticipated to have a difficult airway. 5. Expected to require postoperative transfer to the ICU. 6. History of adrenocortical insufficiency, porphyria, or chronic corticosteroid therapy. 7. Severe arrhythmias, including severe sinus bradycardia (heart rate [HR] = 180 mmHg and/or diastolic blood pressure [DBP] >= 110 mmHg). 9. Abnormal hepatic or renal function (Child–Pugh class B or C; blood urea nitrogen > 1.5 times the upper limit of the normal reference range and/or serum creatinine above the upper limit of the normal reference range). 10. Other patients deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The maximum change in mean arterial pressure;Time of loss of consciousness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in MAP relative to baseline within 5 minutes after tracheal intubation;Heart rate fluctuations during induction of anaesthesia;Occurrence of adverse drug reactions during induction of anaesthesia; | — |
Countries
China
Contacts
Public ContactZhang Huan
Beijing Tsinghua Changgung Hospital
Outcome results
None listed