Women over the age of 38, those who have experienced repeated implantation failures, repeated miscarriages, and patients where either the couple or one of the partners has chromosomal number abnormalities.
Conditions
Interventions
Study Group:When follicles >=14mm reach 50%-80%, administer r-HCG 250ug subcutaneously (when E2 level >3000pg/l, administer GnRH-a 0.2mg subcutaneously)
Control Group:Use conventional triggering criteria (dominant follicle >=18mm one or >=17mm three or >=16mm five, and >=10mm more than six, then administer r-HCG 250ug subcutaneously), when E2 level >3
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. PGT-A indication: women >=38 years, or 2+ recurrent pregnancy loss/miscarriage, or failed implantation after 2 SETs of grade D5 embryos (3 D5/6 blastocysts transferred); 2. Female age >=22 and =6 and AMH >0.6 ng/ml; 4. Antagonist protocol used; 5. ICSI fertilization applied; 6. Each subject enrolled only once; 7. Voluntary informed consent signed by the subject.
Exclusion criteria
Exclusion criteria: 1. Either partner has chromosomal structural abnormality (excluding polymorphisms); 2. Female BMI >30 kg/m²; 3. Endometrial hyperplasia, uterine fibroids >=5cm or any size compressing the endometrium, adenomyosis, uterine malformation, severe intrauterine adhesions, or hydrosalpinx >2cm; 4. Major systemic diseases in female: hypertension, tumors (pituitary, craniopharyngioma, gynecologic malignancies like endometrial cancer), endocrine/metabolic disorders (hyperprolactinemia, Cushing's syndrome, diabetes, thyroid dysfunction), autoimmune diseases (SLE, Sjögren's, MS, rheumatoid arthritis); 5. Severe male factor infertility: sperm concentration 30%, or obstructive azoospermia (donor sperm recipients excluded on this basis only); 6. Standard trigger criteria met: 1 follicle >=18mm OR 3 follicles >=17mm OR 5 follicles >=16mm, with =10mm OR pre-trigger ratio of follicles >=14mm >=50%; 7. Known severe mental illness, inability to understand trial purpose/methods, non-compliance with protocol, or deemed unsuitable by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No. of euploid embryos in the oocyte retrieval cycle; | — |
Secondary
| Measure | Time frame |
|---|---|
| No. of oocytes retrieved;No. of MII;No. of 2PN;Ongoing pregnancy rate;Clinical pregnancy rate of the first embryo transfer;OHSS rate;Miscarriage rate;No. of 2PN cleavage;No. of biopsyable blastocysts;No. high-quality cleavage-stage embryos;Live birth rate; | — |
Countries
China
Contacts
Public ContactHuang Xuefeng
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed