postoperative pain
Conditions
Interventions
Oliceridine group:30 mg of oliceridine fumarate is diluted with 0.9% normal saline to a total volume of 150 mL. An initial loading dose of 7.5 mL is administered. When the patient presses the administ
Modified Oliceridine group:For the optimized patient controlled intravenous analgesia (PCIA) regimen using a biased µ?opioid receptor agonist, a stepwise pulse administration mode combined with on dem
Sufentanil group:For the PCIA regimen using sufentanil, the postoperative continuous analgesia concentration is 0.02 µg/(kg·ml) of sufentanil, with an infusion rate of 2 ml/h, a bolus dose of 0.5 ml,
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I–II 2. BMI 18–24 kg/m² 3. Age 18–50 years 4. Patients scheduled to undergo laparoscopic surgery with an estimated operative time of 2–3 hours
Exclusion criteria
Exclusion criteria: 1. Participation in another clinical trial within 4 weeks prior to the start of this study. 2. Suspected gastrointestinal obstruction, including paralytic ileus. 3. Emergency patients who cannot undergo adequate preoperative preparation. 4. Acute or severe bronchial asthma in an unmonitored setting or without resuscitation equipment. 5. Patients with pre-existing organic heart disease (e.g., sick sinus syndrome, atrioventricular block, etc.). 6. Patients with severe dehydration, electrolyte disturbances, and shock. 7. Female patients who are pregnant, planning pregnancy, or lactating. 8. Patients with pre-existing severe respiratory dysfunction. 9. Patients with a history of neurological or psychiatric disorders, severe alcoholism, or long-term high-dose sedative use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total analgesic consumption within 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale pain score;The number of PCIA demands and the total analgesic dose administered;The incidence and severity of adverse reactions within 24 hours postoperatively and during the 24–48 hour interval; | — |
Countries
China
Contacts
Public ContactMao Xu
Peking University Third Hospital
Outcome results
None listed