Intervertebral Disc Degeneration (IVDD)
Conditions
Interventions
The IVDD patient group:None
Normal control group:None
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion Criteria: 1. Patients aged 35–75 years, regardless of gender, who underwent surgical treatment for lumbar disc degeneration-related diseases (e.g., lumbar disc herniation, lumbar spinal stenosis) or idiopathic scoliosis (requiring lumbar fusion surgery with intraoperative acquisition of normal NP tissue); 2. Patients in the IVDD group: Preoperatively diagnosed as grades IV–V (degenerative group) according to the Pfirrmann classification system via lumbar MRI; 3. Normal control group patients: Those undergoing surgery for idiopathic scoliosis, with intraoperatively obtained NP tissue confirmed pathological normal (Pfirrmann grades II–III) and without clinical symptoms related to lumbar degeneration.
Exclusion criteria
Exclusion criteria: 1. Patients with severe organic spinal lesions (e.g., spinal cord tumors, spinal tuberculosis, spinal fractures, cauda equina syndrome, etc.); 2. Patients with a history of lumbar spine surgery or spinal deformity correction; 3. Patients with severe inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus), infectious diseases, or malignant tumors; 4. Patients who have used anti-inflammatory drugs, immunosuppressants, or Omega-3 fatty acid supplements within one month prior to surgery; 5. Patients with severe hepatic or renal dysfunction, cardiovascular diseases, or coagulation disorders; 6. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MaR1 in NP tissues and serum; | — |
Countries
China
Contacts
Public ContactChen Lv
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed