Adult patients in the emergency department who require treatment with opioid analgesics
Conditions
Interventions
Trial Group:Hydrochloric Acid Hydromorphone Injection. Intravenous maintenance dose 2-5µg/kg/h for non-mechanical ventilation patients
8-15µg/kg/h for mechanical ventilation patients. Target NRS score <=3 points.
Control Group:Citric Acid Fentanyl Injection. Intravenous maintenance dose 0.7-10µg/kg/h. Target NRS score <=3 points.
Sponsors
Xi'an Jiaotong University Second Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Participants must be at least 18 years of age. There will be no restrictions based on gender. 2.Emergency department patients who require opioid analgesic therapy. 3.Informed consent was obtained from the patient or their legal guardian.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women. 2.Known allergy or hypersensitivity to any of the study drugs. 3.Use of any analgesic medications other than hydromorphone or fentanyl within the previous week. 4.History of chronic opioid use or opioid addiction. 5.Hemodynamic or respiratory instability, defined as systolic blood pressure < 90 mm Hg, heart rate < 50 beats per minute, or oxygen saturation < 95%. 6.Intoxication with alcohol or other drugs. 7.Symptoms of respiratory depression, or a diagnosis of acute or severe bronchial asthma. 8.Paralytic or potentially obstructed bowel (e.g., patients with or at risk for gastrointestinal obstruction, particularly paralytic ileus). 9.Hearing or visual impairment, or any other condition that may severely interfere with the collection of study data. 10.Patients with psychiatric or neurological disorders, cognitive or consciousness impairments, who are unable to provide reliable expressions. 11.Previous participation in this study or concurrent participation in any other clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall patient satisfaction in the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to a 2-point reduction in the NRS score from baseline;Analgesic onset time;The number of cases that achieved the target analgesic score (NRS score <= 3);Volume of fluid required for resuscitation;Medical expense;Emergency department length of stay;Vital signs;Total dosage of analgesic drugs used during the study period; | — |
Countries
China
Contacts
Public ContactZhang Zhengliang
Xi'an Jiaotong University Second Affiliated Hospital
Outcome results
None listed