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The Effect of Administration Order of Remimazolam and Propofol on Hiccup Incidence During Painless Gastrointestinal Endoscopy: A Randomized Controlled Study

The Effect of Administration Order of Remimazolam and Propofol on Hiccup Incidence During Painless Gastrointestinal Endoscopy: A Randomized Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124076
Enrollment
Unknown
Registered
2026-05-07
Start date
2025-03-03
Completion date
Unknown
Last updated
2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hiccup

Interventions

Group P: propofol 1 mg/kg bolus and then remimazolam 0.2 mg/kg
Group R:remimazolam 0.2 mg/kg bolus and then propofol 1 mg/kg

Sponsors

Zhejiang Rongjun Hospital, Jiaxing, Zhejiang,China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 80 Years

Inclusion criteria

Inclusion criteria: Aged 25–80 years; Body mass index (BMI) 18.0–30.0 kg/m^2; American Society of Anesthesiologists (ASA) physical status I or II;Gender: No preference

Exclusion criteria

Exclusion criteria: 1. Known allergy or contraindication to remimazolam or propofol; 2. Emergency gastrointestinal bleeding, obstruction, or suspected full stomach; 3. Acute or unstable cardiovascular or cerebrovascular disease; 4. An obvious difficult airway (anticipated); 5. Severe psychiatric disorders or cognitive impairment impairing cooperation; 6. Acute asthma attack; 7. Pre-existing hiccups or symptomatic gastroesophageal reflux disease within 1 week prior to the procedure.

Design outcomes

Primary

MeasureTime frame
The incidence of hiccups;

Secondary

MeasureTime frame
Body movements and other adverse reactions;Hiccup onset timing;Duration of hiccups;

Countries

China

Contacts

Public ContactYulin Dong

Zhejiang Rongjun Hospital, Jiaxing, Zhejiang,China

dyl1329@163.com+86 132 4391 1329

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 16, 2026