Post-thoracoscopic Pain
Conditions
Interventions
low-dose hydrocodone group:Hydromorphone 0.05 mg/kg diluted to 100 mL with 0.9% normal saline and administered via a patient-controlled intravenous analgesia (PCIA) pump.
The medium-dose hydromorphone group:Hydromorphone 0.075 mg/kg diluted to 100 mL with 0.9% normal saline and administered via a patient-controlled intravenous analgesia (PCIA) pump.
High-dose hydrocodone group:Hydromorphone 0.10 mg/kg diluted to 100 mL with 0.9% normal saline and administered via a patient-controlled intravenous analgesia (PCIA) pump.
control group:Sufentanil 2 µg/kg diluted to 100 mL with 0.9% normal saline and administered via a patient-controlled intravenous analgesia (PCIA) pump.
Sponsors
The Second Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 40–75 years, regardless of gender; 2. American Society of Anesthesiologists (ASA) physical status I–III; 3.Scheduled to undergo unilateral video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy under general anesthesia; 4.No significant preoperative cognitive impairment and able to understand pain assessment methods; 5. Signed informed consent before surgery.
Exclusion criteria
Exclusion criteria: 1. Allergy to local anesthetics, hydromorphone, or sufentanil; 2. Combined severe heart, liver, or kidney dysfunction; 3. Long-term use of opioids or history of drug abuse; 4. Mental illness or communication disorders; 5. Conversion from VATS to open chest during surgery; 6. TPVB puncture failure or local anesthetic extravasation; 7. Patients requiring continued mechanical ventilation or ICU admission postoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS (Visual Analogue Scale) scores at rest and during activity at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in VAS scores at key postoperative time points;24-hour rescue analgesic consumption;Analgesia satisfaction score (0–10);Fluctuation range of hemodynamic parameters (heart rate, mean arterial pressure) ; | — |
Countries
China
Contacts
Public ContactSong Jie
The Second Hospital of Anhui Medical University
Outcome results
None listed